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  • 相对于过去常用的肿瘤细胞接种和免疫缺陷小鼠模型,基因修饰小鼠(GEM)模型是建立在天然完整免疫条件下的原发(de novo)肿瘤,因此,作为肿瘤学研究的工具, GEM模型更能…[详细]

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    GEM模型应用范围

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    • 许多抗肿瘤药物在临床试验中未能达到临床前实验的期望目的,已经成为目前肿瘤学与转化癌症医学所面临的巨… [详细]

    赛业生物

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    俞晓峰
    赛业模式动物高级副总裁、高级科学家
     
    俞晓峰博士,国际知名模式动物和细胞生物学专家,先后就任于耶鲁大学医学院、iTL基因打靶公司和纽约大学医学院以及美国ASC生物技术公司等机构,在遗传修饰模式动物领域有超过20年的研发和管理经验。目前任职于赛业生物科技,任高级副总裁和高级科学家,主要负责基因修饰模式动物平台的技术工作,其研究成果多次发表在Nat Immunol、Mol Cell Biol等高水平杂志上。
     
     
    赛业生物科技集团是全球领先的多元化跨国生物科技实体,2006年成立于美国,中国区总部设立在广州,并在苏州设有子公司,北京、上海、武汉、重庆等地均有办事处。目前员工人数达400余名,总规模超22000平方米,业务经营范围涵盖模式动物、细胞生物学、分子生物学、生物信息学等生命科学领域的多个分支学科。
     
    我们的成就:
     
    全球领先的模式动物商业技术平台
     
    全球最大的科研干细胞库
     
    革命性实验室耗材的领跑者
     
    功能强大的在线免费载体与打靶方案设计工具:
     
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    联系电话:400-680-8038    邮箱:info@cyagen.com
     

    主要参考文献:

    1.  Li K,  Wang F,Cao WB,  and ZW et al (2017)  TRIB3 Promotes APL Progression
    through Stabilization of the Oncoprotein PML-RARa and Inhibition of p53-Mediated Senescence. Cancer Cell 31, 697–710

    2. Tang X,Shi L,and Liu B et al (2017) SIRT7 antagonizes TGF-β signaling and inhibits breast cancer metastasis. Nature Communications 8: 318

    1. Liu C, Ren YF,  Yi Lv and Xu-Feng Zhan et al (2017) Activation of SRY Accounts for Male-Specific Hepatocarcinogenesis: Implication in Gender Disparity of Hepatocellular Carcinoma. Cancer Letters 410: 20-31

    3. Chunga WJ,  Daemena A, Melissa R, and Junttila MR et al (2017) Kras mutant genetically engineered mouse models of human cancers are genomically heterogeneous. PNAS Dec 4, E10947–E10955

    4. Annunziato S, Kas SM, Nethe M, and Drenth AP et al (2016) Modeling invasive lobular breast carcinoma by CRISPR/Cas9-mediated somatic genome editing of the mammary gland. Genes Dev 30: 1470 – 1480

    5. Drost R, Dhillon KK, and Schut E et al (2016) BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1. J Clin Invest 126: 2903 – 2918

    6. Maresch R, Mueller S, and Barenboim M et al (2016) Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/ Cas9 delivery in mice. Nat Commun 7: 10770

    7. Chiou SH, Winters IP, Wang J,  and Chuang CH et al (2015) Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/Cas9-mediated somatic genome editing. Genes Dev 29: 1576 – 1585

    8. Weber J, Öllinger R, and Engleitner T et al (2015) CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice. Proc Natl Acad Sci USA 112: 13982 – 13987

    9. Dow LE, O’Rourke KP,  and Lowe SW et al (2015b) Apc restoration promotes cellular differentiation and reestablishes Crypt homeostasis in colorectal cancer. Cell 161:1539 – 1552

    10. Henneman L, van Miltenburg MH, and Schlicker A et al (2015) Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer. Proc Natl Acad Sci USA 112: 8409 – 8414

    11. Clohessy JG, Pandolfi PP (2015) Mouse hospital and co-clinical trial project- from bench to bedside. Nat Rev Clin Oncol 12: 491 – 498

    12. Cong L, Ran FA, Cox D,  and Marraffini LA et al (2013) Multiplex genome engineering using CRISPR/Cas systems. Science 339: 819 – 823

    13. Jamieson T, Clarke M, and Nibbs RJB et al (2012) Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis. J Clin Invest 122: 3127 – 3144

    14. Drake AC, Chen Q, Chen J (2012) Engineering humanized mice for improved hematopoietic reconstitution. Cell Mol Immunol 9: 215 – 224

    15. Liu P, Cheng H, and Fox EA et al (2011) Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway- independent mechanisms. Nat Med 17: 1116 – 1120

    16. Martins CP, Brown-Swigart L, and Evan GI (2006) Modeling the therapeutic efficacy of p53 restoration in tumors. Cell 127: 1323 – 1334

    17.  Shibata H, Toyama K, Shioya H, and Toyoshima K et al (1997) Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science 278: 120 – 123

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